:root {
  --navy: #071b2b;
  --navy-2: #0d2b3e;
  --ink: #142733;
  --muted: #5a6b73;
  --warm: #f5f0e6;
  --pale: #e9f3f1;
  --white: #fffdf8;
  --teal: #24b9ad;
  --teal-bright: #4ddacb;
  --orange: #f58b4b;
  --orange-pale: #ffe1cb;
  --line: rgba(15, 43, 57, .15);
  --shadow: 0 18px 50px rgba(7, 27, 43, .12);
  --radius: 22px;
  --content: 1280px;
}

* { box-sizing: border-box; }
html { scroll-behavior: smooth; scroll-padding-top: 84px; }
body {
  margin: 0;
  color: var(--ink);
  background: var(--white);
  font-family: "Microsoft YaHei UI", "Microsoft YaHei", system-ui, sans-serif;
  font-size: 18px;
  line-height: 1.72;
  text-rendering: optimizeLegibility;
}
button, input, select { font: inherit; }
a { color: inherit; }
p, h1, h2, h3, ol, ul { margin-top: 0; }
h1, h2, h3, b, strong { font-weight: 700; }
h1, h2, h3 { line-height: 1.18; letter-spacing: -.025em; }
h2 { font-size: clamp(2rem, 3vw, 3.3rem); margin-bottom: 0; }
h3 { font-size: clamp(1.3rem, 1.8vw, 1.75rem); }
small { font-size: .82rem; }
code { padding: .12em .34em; border-radius: 5px; background: rgba(7, 27, 43, .08); }

#scroll-progress {
  position: fixed;
  inset: 0 auto auto 0;
  z-index: 1000;
  width: 0;
  height: 4px;
  background: linear-gradient(90deg, var(--orange), var(--teal-bright));
}

.site-header {
  position: sticky;
  top: 0;
  z-index: 100;
  display: flex;
  align-items: center;
  justify-content: space-between;
  min-height: 72px;
  padding: 0 max(24px, calc((100vw - var(--content)) / 2));
  color: #fff;
  background: rgba(7, 27, 43, .94);
  border-bottom: 1px solid rgba(255,255,255,.12);
  backdrop-filter: blur(18px);
}
.brand { display: flex; align-items: center; gap: 11px; font-weight: 700; text-decoration: none; }
.brand-mark {
  display: inline-grid;
  place-items: center;
  width: 34px;
  height: 34px;
  color: var(--navy);
  background: var(--teal-bright);
  border-radius: 50% 50% 50% 10%;
  font-family: Georgia, serif;
  font-size: 1.25rem;
  font-style: italic;
}
.site-header nav { display: flex; align-items: center; gap: 23px; }
.site-header nav a { color: rgba(255,255,255,.78); font-size: .86rem; text-decoration: none; }
.site-header nav a:hover, .site-header nav a:focus-visible { color: #fff; }
.nav-toggle { display: none; color: #fff; background: transparent; border: 1px solid rgba(255,255,255,.35); border-radius: 10px; padding: 7px 13px; }

.hero {
  overflow: hidden;
  color: #fff;
  background:
    radial-gradient(circle at 76% 18%, rgba(36,185,173,.22), transparent 25%),
    radial-gradient(circle at 8% 82%, rgba(245,139,75,.18), transparent 28%),
    var(--navy);
}
.hero-inner {
  display: grid;
  grid-template-columns: 1.17fr .83fr;
  gap: clamp(42px, 7vw, 100px);
  align-items: center;
  max-width: var(--content);
  min-height: 670px;
  margin: 0 auto;
  padding: 90px 24px 78px;
}
.eyebrow { margin-bottom: 18px; color: var(--teal-bright); font-size: .78rem; font-weight: 700; letter-spacing: .16em; }
.eyebrow.dark { color: #087e77; }
.hero h1 { max-width: 850px; margin-bottom: 26px; font-size: clamp(3rem, 5.4vw, 5.7rem); }
.hero h1 span { color: var(--teal-bright); }
.hero-deck { max-width: 780px; color: rgba(255,255,255,.78); font-size: 1.08rem; }
.hero-actions { display: flex; flex-wrap: wrap; gap: 14px; margin: 34px 0 25px; }
.button { display: inline-flex; min-height: 50px; align-items: center; justify-content: center; padding: 11px 21px; border: 1px solid transparent; border-radius: 99px; font-weight: 700; text-decoration: none; }
.button.primary { color: var(--navy); background: var(--orange); }
.button.secondary { border-color: rgba(255,255,255,.42); color: #fff; }
.button:hover { transform: translateY(-2px); }
.hero-note { margin-bottom: 0; color: rgba(255,255,255,.54); font-size: .8rem; }
.verdict-panel {
  position: relative;
  padding: 36px;
  background: rgba(255,255,255,.08);
  border: 1px solid rgba(255,255,255,.16);
  border-radius: 30px;
  box-shadow: 0 30px 90px rgba(0,0,0,.22);
  backdrop-filter: blur(14px);
}
.verdict-panel::before { content: ""; position: absolute; inset: -1px -1px auto 35px; width: 120px; height: 4px; background: var(--orange); }
.panel-kicker { color: var(--orange); font-size: .78rem; font-weight: 700; letter-spacing: .15em; }
.verdict-panel h2 { margin-bottom: 30px; font-size: clamp(1.55rem, 2.4vw, 2.4rem); }
.verdict-row { display: grid; grid-template-columns: 150px 1fr; gap: 20px; align-items: center; padding: 21px 0; border-top: 1px solid rgba(255,255,255,.14); }
.verdict-number { color: var(--orange); font-size: 2rem; font-weight: 700; letter-spacing: -.04em; }
.verdict-row.china .verdict-number { color: var(--teal-bright); }
.verdict-row b, .verdict-row small { display: block; }
.verdict-row small { margin-top: 3px; color: rgba(255,255,255,.6); line-height: 1.45; }
.panel-bottom { margin: 20px 0 0; padding-top: 19px; color: rgba(255,255,255,.62); border-top: 1px solid rgba(255,255,255,.14); font-size: .84rem; }
.hero-metrics { display: grid; grid-template-columns: repeat(6, 1fr); max-width: var(--content); margin: 0 auto; padding: 0 24px 42px; }
.hero-metrics article { padding: 18px 22px; border-left: 1px solid rgba(255,255,255,.15); }
.hero-metrics strong, .hero-metrics span, .hero-metrics small { display: block; }
.hero-metrics strong { color: var(--orange); font-size: 1.72rem; line-height: 1.2; }
.hero-metrics span { margin: 6px 0 3px; font-size: .78rem; font-weight: 700; }
.hero-metrics small { color: rgba(255,255,255,.48); line-height: 1.4; }

.section { padding: 108px max(24px, calc((100vw - var(--content)) / 2)); }
.section.warm { background: var(--warm); }
.section.white { background: var(--white); }
.section.pale { background: var(--pale); }
.section.navy { color: #fff; background: var(--navy); }
.section-heading { margin-bottom: 50px; }
.split-heading { display: grid; grid-template-columns: 1.12fr .68fr; gap: 60px; align-items: end; }
.split-heading > p, .section-heading.inverse > p { margin-bottom: 4px; color: var(--muted); }
.section-heading.inverse { display: grid; grid-template-columns: 1.12fr .68fr; gap: 60px; align-items: end; }
.section-heading.inverse > p { color: rgba(255,255,255,.62); }

.price-thesis { display: grid; grid-template-columns: 1fr 1fr; gap: 24px; }
.thesis-card { overflow: hidden; background: #fff; border-radius: var(--radius); box-shadow: var(--shadow); }
.thesis-head { display: flex; gap: 13px; align-items: center; padding: 20px 27px; color: #fff; background: var(--navy); }
.thesis-head span { padding: 4px 10px; color: var(--navy); background: var(--orange); border-radius: 99px; font-size: .76rem; font-weight: 700; }
.cn-card .thesis-head span { background: var(--teal-bright); }
.probability-list { padding: 17px 27px 29px; }
.probability-item { display: grid; grid-template-columns: 1fr auto; gap: 18px; align-items: start; margin-top: 18px; }
.probability-item b, .probability-item span { display: block; }
.probability-item span { margin-top: 3px; color: var(--muted); font-size: .84rem; line-height: 1.55; }
.probability-item strong { color: var(--orange); font-size: 1.4rem; }
.cn-card .probability-item strong { color: #07867e; }
.probability-item strong em { display: block; margin-top: 2px; color: var(--muted); font-size: .62rem; font-style: normal; font-weight: 400; white-space: nowrap; }
.probability-bar { height: 6px; margin-top: 11px; background: #edf0ed; border-radius: 99px; }
.probability-bar i { display: block; height: 100%; background: var(--orange); border-radius: inherit; }
.probability-bar.cn i { background: var(--teal); }
.model-disclaimer { margin: 18px 0 0; padding: 15px 18px; color: var(--muted); background: rgba(255,255,255,.62); border: 1px solid var(--line); border-radius: 12px; font-size: .8rem; }
.model-disclaimer b { color: #8b3919; }

.economics-grid { display: grid; grid-template-columns: 1.25fr .75fr; gap: 24px; margin-top: 24px; }
.economics-panel { padding: 31px; background: rgba(255,255,255,.68); border: 1px solid var(--line); border-radius: var(--radius); }
.mini-label { margin-bottom: 7px; color: #087e77; font-size: .76rem; font-weight: 700; letter-spacing: .13em; }
.ladder { margin: 28px 0 20px; }
.ladder-row { position: relative; display: grid; grid-template-columns: 220px 1fr 112px; gap: 16px; align-items: center; margin: 13px 0; }
.ladder-row span { font-size: .85rem; }
.ladder-row i { position: relative; height: 18px; background: #d9e5e1; border-radius: 99px; }
.ladder-row i::before { content: ""; display: block; width: var(--w); height: 100%; background: #6c8a8b; border-radius: inherit; }
.ladder-row.hot i::before { background: var(--orange); }
.ladder-row.combo i::before { background: var(--teal); }
.ladder-row b { text-align: right; }
.note { margin-bottom: 0; color: var(--muted); font-size: .82rem; }
.margin-cases { display: grid; gap: 12px; margin: 30px 0 22px; }
.margin-cases div { display: grid; grid-template-columns: 1fr 90px 130px; gap: 15px; align-items: center; padding: 15px 18px; background: #edf1ec; border-radius: 13px; }
.margin-cases strong { color: var(--navy); font-size: 1.18rem; }
.margin-cases em { color: #087e77; font-size: .78rem; font-style: normal; font-weight: 700; text-align: right; }
.margin-cases .featured { color: #fff; background: var(--navy); }
.margin-cases .featured strong { color: var(--teal-bright); }
.decision-callout { display: grid; grid-template-columns: 220px 1fr; gap: 34px; margin-top: 24px; padding: 31px; color: #fff; background: var(--navy); border-radius: var(--radius); }
.decision-callout b { color: var(--orange); }
.decision-callout p { margin: 0; }
.price-detail-block { margin-top: 42px; }
.subsection-heading { display: grid; grid-template-columns: 1fr .75fr; gap: 40px; align-items: end; margin-bottom: 20px; }
.subsection-heading > p { margin: 0; color: var(--muted); font-size: .84rem; }
.subsection-heading h3 { margin-bottom: 0; }
.price-scenario-table { min-width: 1040px; }
.price-scenario-table td { white-space: nowrap; }
.price-scenario-table .featured-row { background: var(--pale); }
.payer-grid { display: grid; grid-template-columns: 1fr 1fr; gap: 24px; margin-top: 24px; }
.payer-card { padding: 30px; background: #fff; border: 1px solid var(--line); border-radius: var(--radius); }
.payer-card ul { margin: 22px 0; padding-left: 22px; }
.payer-card li { padding: 5px 0; color: var(--muted); font-size: .84rem; }
.payer-card p:not(.mini-label) { color: var(--muted); font-size: .84rem; }
.split-payment { display: grid; grid-template-columns: 1fr 1fr; gap: 12px; margin: 22px 0; }
.split-payment div { padding: 17px; background: var(--pale); border-radius: 12px; }
.split-payment span, .split-payment b, .split-payment em { display: block; }
.split-payment span { color: var(--muted); font-size: .72rem; }
.split-payment b { margin: 5px 0; color: #087e77; }
.split-payment em { font-size: .8rem; font-style: normal; }
.inline-links { display: flex; flex-wrap: wrap; gap: 9px; margin-top: 18px; }
.inline-links a { padding: 7px 10px; color: #087e77; background: var(--pale); border-radius: 8px; font-size: .73rem; font-weight: 700; text-decoration: none; }

.scenario-switch { display: inline-flex; flex-wrap: wrap; gap: 7px; padding: 6px; background: rgba(255,255,255,.08); border-radius: 16px; }
.scenario-switch button { padding: 10px 17px; color: rgba(255,255,255,.68); background: transparent; border: 0; border-radius: 11px; cursor: pointer; }
.scenario-switch button.active { color: var(--navy); background: var(--teal-bright); font-weight: 700; }
.calculator-grid { display: grid; grid-template-columns: .9fr 1.1fr; gap: 24px; margin-top: 25px; }
.control-panel { padding: 28px; background: rgba(255,255,255,.07); border: 1px solid rgba(255,255,255,.13); border-radius: var(--radius); }
.control-panel label { display: block; margin-bottom: 24px; }
.control-panel label:last-child { margin-bottom: 0; }
.control-panel label > span { display: flex; justify-content: space-between; gap: 15px; margin-bottom: 6px; color: rgba(255,255,255,.75); font-size: .85rem; }
.control-panel output { color: var(--teal-bright); font-weight: 700; }
input[type="range"] { width: 100%; accent-color: var(--orange); cursor: pointer; }
.output-panel { display: grid; grid-template-columns: repeat(2, 1fr); gap: 12px; }
.output-panel article { padding: 23px; background: rgba(255,255,255,.07); border: 1px solid rgba(255,255,255,.12); border-radius: 17px; }
.output-panel span, .output-panel strong, .output-panel small { display: block; }
.output-panel span { color: rgba(255,255,255,.63); font-size: .8rem; }
.output-panel strong { margin: 6px 0; font-size: clamp(1.45rem, 2.5vw, 2.35rem); }
.output-panel small { color: rgba(255,255,255,.45); }
.output-panel .accent { border-color: rgba(245,139,75,.55); background: rgba(245,139,75,.1); }
.output-panel .accent strong { color: var(--orange); }
.output-panel .accent-cn { border-color: rgba(77,218,203,.45); background: rgba(77,218,203,.08); }
.output-panel .accent-cn strong { color: var(--teal-bright); }
.calculator-note { margin: 21px 0 0; padding: 15px 19px; color: rgba(255,255,255,.75); background: rgba(255,255,255,.06); border-left: 4px solid var(--orange); }

.science-overview { display: grid; grid-template-columns: .85fr 1.15fr; gap: 48px; align-items: center; margin-bottom: 48px; }
.pyramid { display: flex; flex-direction: column; align-items: center; gap: 6px; }
.pyramid-level { padding: 16px 25px; color: #fff; background: var(--navy); text-align: center; clip-path: polygon(10% 0,90% 0,100% 100%,0 100%); }
.pyramid-level b, .pyramid-level span { display: block; }
.pyramid-level span { margin-top: 3px; color: rgba(255,255,255,.64); font-size: .78rem; line-height: 1.45; }
.pyramid-level.top { width: 57%; background: #087e77; }
.pyramid-level.middle { width: 78%; }
.pyramid-level.bottom { width: 100%; background: #526570; }
.science-rules { padding: 31px; background: rgba(255,255,255,.58); border: 1px solid var(--line); border-radius: var(--radius); }
.science-rules ol { margin: 0; padding-left: 24px; }
.science-rules li { padding: 7px 0; }

.table-wrap { overflow-x: auto; border: 1px solid var(--line); border-radius: var(--radius); box-shadow: 0 12px 35px rgba(7,27,43,.07); }
.data-table { width: 100%; min-width: 980px; border-collapse: collapse; background: #fff; }
.data-table th { padding: 17px 18px; color: #fff; background: var(--navy); font-size: .77rem; text-align: left; white-space: nowrap; }
.data-table td { padding: 18px; border-bottom: 1px solid var(--line); vertical-align: top; }
.data-table tbody tr:last-child td { border-bottom: 0; }
.data-table tbody tr:hover { background: #f4f8f6; }
.rank-number { display: inline-grid; place-items: center; width: 35px; height: 35px; color: #fff; background: var(--navy); border-radius: 50%; font-weight: 700; }
.cancer-cell b, .cancer-cell span { display: block; }
.cancer-cell span, .evidence-cell span { color: var(--muted); font-size: .76rem; line-height: 1.45; }
.prob-cell { min-width: 128px; }
.prob-cell strong { color: #087e77; font-size: 1.22rem; }
.mini-bar { display: block; width: 100%; height: 5px; margin-top: 6px; background: #e6ece8; border-radius: 99px; }
.mini-bar i { display: block; height: 100%; background: var(--teal); border-radius: inherit; }
.phase-number { font-weight: 700; }
.evidence-cell { min-width: 280px; }
.evidence-cell b { display: block; margin-bottom: 4px; }
.table-footnote { margin: 15px 7px 0; color: var(--muted); font-size: .78rem; }

.market-controls { display: grid; grid-template-columns: repeat(4, 1fr); gap: 12px; padding: 24px; background: var(--navy); border-radius: var(--radius); }
.market-controls label { padding: 7px 10px; }
.market-controls span, .market-controls output { display: block; color: rgba(255,255,255,.68); font-size: .78rem; }
.market-controls output { margin-top: 5px; color: var(--teal-bright); font-size: 1.02rem; font-weight: 700; }
.market-summary { display: grid; grid-template-columns: repeat(4, 1fr); gap: 12px; margin: 15px 0 26px; }
.market-summary article { padding: 21px; background: var(--pale); border-radius: 15px; }
.market-summary span, .market-summary strong { display: block; }
.market-summary span { color: var(--muted); font-size: .77rem; }
.market-summary strong { margin-top: 6px; color: var(--navy); font-size: 1.55rem; }
.market-cell strong, .market-cell span { display: block; }
.market-cell span { color: var(--muted); font-size: .75rem; }
.incidence-cell b, .incidence-cell span { display: block; }
.incidence-cell span { color: var(--muted); font-size: .73rem; }

.company-grid { display: grid; grid-template-columns: repeat(4, 1fr); gap: 17px; }
.company-card { display: flex; min-height: 315px; flex-direction: column; padding: 25px; background: #fff; border: 1px solid rgba(7,27,43,.11); border-radius: 18px; box-shadow: 0 10px 30px rgba(7,27,43,.06); }
.company-card:hover { transform: translateY(-3px); box-shadow: var(--shadow); }
.company-type { color: #087e77; font-size: .74rem; font-weight: 700; letter-spacing: .05em; }
.company-card h3 { margin: 11px 0 4px; font-size: 1.25rem; }
.company-asset { color: var(--muted); font-size: .8rem; }
.company-stage { margin: 12px 0; padding: 9px 11px; background: var(--pale); border-radius: 9px; font-size: .76rem; }
.company-card p { color: var(--muted); font-size: .82rem; }
.company-card a { margin-top: auto; color: #087e77; font-size: .82rem; font-weight: 700; }
.inline-source { display: inline-block; margin-top: 7px; color: #087e77; font-weight: 700; text-decoration: none; }

.timeline { display: grid; grid-template-columns: repeat(6, 1fr); gap: 14px; }
.timeline article { position: relative; min-height: 260px; padding: 24px 20px; background: rgba(255,255,255,.07); border: 1px solid rgba(255,255,255,.12); border-radius: 17px; }
.timeline article::after { content: "→"; position: absolute; right: -15px; top: 48px; z-index: 2; color: var(--orange); font-size: 1.4rem; }
.timeline article:last-child::after { display: none; }
.timeline span { color: var(--orange); font-size: 1.5rem; font-weight: 700; }
.timeline b, .timeline p { display: block; }
.timeline b { margin: 15px 0 8px; }
.timeline p { color: rgba(255,255,255,.6); font-size: .8rem; line-height: 1.55; }
.schedule-note-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 14px; margin-top: 16px; }
.schedule-note-grid article { padding: 22px; background: rgba(77,218,203,.08); border: 1px solid rgba(77,218,203,.25); border-radius: 15px; }
.schedule-note-grid b { color: var(--teal-bright); }
.schedule-note-grid p { margin: 8px 0 0; color: rgba(255,255,255,.62); font-size: .82rem; }
.schedule-caveat { margin-top: 16px; padding: 20px 23px; color: rgba(255,255,255,.7); background: rgba(245,139,75,.09); border: 1px solid rgba(245,139,75,.35); border-radius: 15px; font-size: .82rem; }
.schedule-caveat b { color: var(--orange); }
.schedule-caveat span { display: flex; flex-wrap: wrap; gap: 9px; margin-top: 10px; }
.schedule-caveat a { padding: 5px 9px; color: var(--teal-bright); background: rgba(255,255,255,.07); border-radius: 7px; text-decoration: none; }

.evidence-stats { display: grid; grid-template-columns: repeat(6, 1fr); gap: 12px; margin-bottom: 16px; }
.evidence-stats article { padding: 20px; background: #fff; border-radius: 15px; text-align: center; }
.evidence-stats strong, .evidence-stats span { display: block; }
.evidence-stats strong { color: #087e77; font-size: 1.8rem; }
.evidence-stats span { color: var(--muted); font-size: .78rem; }
.evidence-warning { display: flex; gap: 15px; margin: 16px 0 26px; padding: 17px 20px; color: #fff; background: var(--navy); border-radius: 13px; }
.evidence-warning b { color: var(--orange); white-space: nowrap; }
.evidence-warning span { color: rgba(255,255,255,.68); font-size: .84rem; }
.metadata-coverage { display: grid; grid-template-columns: repeat(5, minmax(0, 1fr)); gap: 10px; margin: 16px 0 26px; padding: 18px; background: #fff; border: 1px solid var(--line); border-radius: 17px; }
.metadata-coverage div { padding: 12px 14px; background: var(--pale); border-radius: 11px; }
.metadata-coverage span, .metadata-coverage b { display: block; }
.metadata-coverage span { color: var(--muted); font-size: .7rem; }
.metadata-coverage b { margin-top: 3px; color: #087e77; font-size: 1.28rem; }
.metadata-coverage p { grid-column: 1 / -1; margin: 4px 5px 0; color: var(--muted); font-size: .76rem; }
.filter-bar { display: grid; grid-template-columns: 1.4fr repeat(3, 1fr); gap: 10px; align-items: end; padding: 20px; background: rgba(255,255,255,.65); border: 1px solid var(--line); border-radius: 17px; }
.filter-bar label span { display: block; margin-bottom: 5px; color: var(--muted); font-size: .72rem; font-weight: 700; }
.filter-bar input, .filter-bar select { width: 100%; min-height: 46px; padding: 8px 11px; color: var(--ink); background: #fff; border: 1px solid #c9d2ce; border-radius: 9px; }
.small-button, .text-button { min-height: 46px; padding: 8px 15px; color: #fff; background: var(--navy); border: 0; border-radius: 9px; cursor: pointer; }
.text-button { min-height: auto; padding: 0; color: #087e77; background: transparent; }
.evidence-toolbar { display: flex; justify-content: space-between; margin: 20px 4px 12px; color: var(--muted); font-size: .82rem; }
.trial-list { display: grid; gap: 13px; }
.trial-card { overflow: hidden; background: #fff; border: 1px solid var(--line); border-radius: 17px; }
.trial-card-head { padding: 22px 24px 14px; }
.trial-card-head > p { margin: 7px 0 0; color: var(--muted); font-size: .78rem; }
.trial-title { display: flex; flex-wrap: wrap; gap: 8px; align-items: center; }
.trial-title b { font-size: 1.05rem; }
.trial-subline { display: flex; flex-wrap: wrap; gap: 9px 16px; margin-top: 7px; color: var(--muted); font-size: .76rem; }
.pill { display: inline-flex; align-items: center; padding: 3px 9px; color: var(--navy); background: var(--pale); border-radius: 99px; font-size: .7rem; font-weight: 700; }
.pill.positive { color: #07584e; background: #ccece5; }
.pill.negative { color: #8b3919; background: var(--orange-pale); }
.pill.mixed { color: #725a00; background: #f6e9b5; }
.trial-meta-strip { display: grid; grid-template-columns: repeat(3, 1fr); gap: 1px; background: var(--line); border-block: 1px solid var(--line); }
.trial-meta-strip > div { min-width: 0; padding: 13px 17px; background: #f8faf7; }
.trial-meta-strip span, .trial-meta-strip b { display: block; }
.trial-meta-strip span { color: var(--muted); font-size: .66rem; }
.trial-meta-strip b { overflow-wrap: anywhere; margin-top: 3px; font-size: .77rem; line-height: 1.45; }
.profile-links { display: flex !important; flex-wrap: wrap; gap: 5px; }
.profile-links a { color: #087e77; text-decoration: none; }
.unknown-value { color: var(--muted); font-weight: 400; }
.trial-card-actions { display: flex; align-items: center; justify-content: space-between; gap: 18px; padding: 15px 24px; }
.trial-card-actions > span { color: var(--muted); font-size: .72rem; text-align: right; }
.profile-button, .table-profile-button { min-height: 42px; padding: 8px 15px; color: #fff; background: #087e77; border: 0; border-radius: 9px; font-weight: 700; cursor: pointer; }
.table-profile-button { min-height: 36px; padding: 6px 10px; font-size: .72rem; white-space: nowrap; }
.trial-quick { border-top: 1px solid var(--line); }
.trial-quick summary { display: grid; grid-template-columns: 1fr auto; gap: 18px; padding: 15px 24px; color: #087e77; cursor: pointer; list-style: none; font-size: .76rem; font-weight: 700; }
.trial-quick summary::-webkit-details-marker { display: none; }
.trial-quick summary::after { content: "+"; display: grid; place-items: center; width: 27px; height: 27px; color: #fff; background: var(--navy); border-radius: 50%; font-size: 1rem; }
.trial-quick[open] summary::after { content: "−"; background: #087e77; }
.trial-body { padding: 0 24px 25px; border-top: 1px solid var(--line); }
.trial-status { margin: 19px 0; padding: 12px 15px; color: var(--navy); background: var(--pale); border-left: 4px solid var(--teal); }
.trial-data-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 13px; }
.trial-data-grid article { padding: 17px; background: #f7f8f4; border-radius: 12px; }
.trial-data-grid b { display: block; margin-bottom: 6px; color: #087e77; font-size: .78rem; }
.trial-data-grid p { margin: 0; color: var(--muted); font-size: .78rem; }
.critique { margin: 14px 0; padding: 17px; color: #fff; background: var(--navy); border-radius: 12px; font-size: .83rem; }
.critique b { color: var(--orange); }
.source-row { display: flex; flex-wrap: wrap; gap: 9px; }
.source-row a { padding: 6px 10px; color: #087e77; background: var(--pale); border-radius: 7px; font-size: .72rem; font-weight: 700; text-decoration: none; }
.empty { padding: 50px; color: var(--muted); background: #fff; border-radius: 17px; text-align: center; }

.china-trial-section { margin-top: 92px; padding-top: 68px; border-top: 2px solid var(--line); }
.china-stats { display: grid; grid-template-columns: repeat(6, minmax(0, 1fr)); gap: 12px; margin-bottom: 14px; }
.china-stats article { padding: 18px; background: #fff; border: 1px solid var(--line); border-radius: 13px; }
.china-stats strong, .china-stats span { display: block; }
.china-stats strong { color: #087e77; font-size: 1.55rem; }
.china-stats span { color: var(--muted); font-size: .72rem; }
.china-scope-note { margin-bottom: 14px; padding: 15px 18px; color: var(--muted); background: var(--orange-pale); border-radius: 12px; font-size: .78rem; }
.china-scope-note b { color: #8b3919; }
.china-filter-bar { display: grid; grid-template-columns: 1.5fr repeat(3, 1fr) auto; gap: 10px; align-items: end; padding: 18px; background: rgba(255,255,255,.65); border: 1px solid var(--line); border-radius: 15px; }
.china-filter-bar label span { display: block; margin-bottom: 5px; color: var(--muted); font-size: .72rem; font-weight: 700; }
.china-filter-bar input, .china-filter-bar select { width: 100%; min-height: 44px; padding: 8px 10px; background: #fff; border: 1px solid #c9d2ce; border-radius: 8px; }
.china-trial-table { min-width: 1500px; }
.china-trial-table td { font-size: .76rem; }

.evidence-dialog { width: min(1100px, calc(100% - 36px)); max-height: 90vh; padding: 0; color: var(--ink); background: var(--white); border: 0; border-radius: 23px; box-shadow: 0 30px 100px rgba(0,0,0,.35); }
.evidence-dialog::backdrop { background: rgba(3,17,27,.76); backdrop-filter: blur(5px); }
.dialog-shell { position: relative; }
.dialog-topbar { position: sticky; top: 0; z-index: 3; display: flex; align-items: center; justify-content: space-between; padding: 13px 20px; color: var(--teal-bright); background: var(--navy); font-size: .7rem; font-weight: 700; letter-spacing: .12em; }
.dialog-close { display: grid; place-items: center; width: 38px; height: 38px; color: #fff; background: rgba(255,255,255,.1); border: 1px solid rgba(255,255,255,.24); border-radius: 50%; font-size: 1.35rem; cursor: pointer; }
#trial-dialog-content, #china-dialog-content { padding: 34px; }
.dialog-heading { display: grid; grid-template-columns: 1fr auto; gap: 22px; align-items: start; padding-bottom: 27px; border-bottom: 1px solid var(--line); }
.dialog-heading h2 { font-size: clamp(1.8rem, 3vw, 3rem); }
.dialog-heading p:not(.mini-label) { margin: 10px 0 0; color: var(--muted); }
.profile-section { padding: 28px 0; border-bottom: 1px solid var(--line); }
.profile-section:last-child { border-bottom: 0; }
.profile-section h3 { margin-bottom: 17px; font-size: 1.25rem; }
.profile-grid { display: grid; grid-template-columns: repeat(3, 1fr); gap: 10px; }
.profile-grid > div { padding: 15px; background: #f4f7f3; border-radius: 11px; }
.profile-grid span, .profile-grid b { display: block; }
.profile-grid span { color: var(--muted); font-size: .68rem; }
.profile-grid b { margin-top: 4px; font-size: .8rem; line-height: 1.5; overflow-wrap: anywhere; }
.dialog-data-grid article { background: #f4f7f3; }
.evidence-assessment { margin-top: 4px; padding: 25px; color: #fff; background: var(--navy); border: 0; border-radius: 15px; }
.evidence-assessment h3 { margin-bottom: 10px; }
.evidence-assessment > p:not(.mini-label) { color: rgba(255,255,255,.75); }
.assessment-tags { display: flex; flex-wrap: wrap; gap: 7px; margin-top: 17px; }
.assessment-tags span { padding: 5px 9px; color: var(--navy); background: var(--teal-bright); border-radius: 99px; font-size: .68rem; font-weight: 700; }
.profile-note { color: var(--muted); }
.metadata-note { margin: 16px 0 0; padding: 15px 17px; background: #fff4e9; border-left: 4px solid var(--orange); border-radius: 8px; }

.route-grid { display: grid; grid-template-columns: repeat(4, 1fr); gap: 16px; }
.route-card { display: flex; min-height: 330px; flex-direction: column; padding: 27px; background: var(--warm); border: 1px solid var(--line); border-radius: 18px; }
.route-card span { color: #087e77; font-size: .72rem; font-weight: 700; letter-spacing: .06em; }
.route-card h3 { margin: 16px 0 12px; }
.route-card p { color: var(--muted); font-size: .84rem; }
.route-card > b { margin-top: auto; color: #087e77; font-size: .8rem; }
.route-card.recommended { color: #fff; background: var(--navy); }
.route-card.recommended p { color: rgba(255,255,255,.64); }
.route-card.recommended > b { color: var(--teal-bright); }
.route-card.muted { opacity: .72; }
.strategy-grid { display: grid; grid-template-columns: .82fr 1.18fr; gap: 20px; margin-top: 20px; }
.gate-panel, .choice-panel { padding: 30px; border-radius: var(--radius); }
.gate-panel { color: #fff; background: var(--navy); }
.gate-panel ul { margin-bottom: 0; padding-left: 22px; color: rgba(255,255,255,.68); }
.gate-panel li { padding: 5px 0; }
.choice-panel { display: grid; gap: 13px; background: var(--pale); }
.choice-panel div { padding: 15px 18px; background: rgba(255,255,255,.65); border-radius: 12px; }
.choice-panel span { color: #087e77; font-size: .72rem; font-weight: 700; }
.choice-panel h3 { margin: 4px 0 7px; font-size: 1.25rem; }
.choice-panel p { margin: 0; color: var(--muted); font-size: .8rem; }
.ninety-days { display: grid; grid-template-columns: 150px 1fr; gap: 30px; margin-top: 20px; padding: 30px; background: var(--orange-pale); border-radius: var(--radius); }
.ninety-days ol { margin: 0; padding-left: 22px; }
.ninety-days li { padding: 5px 0; }

.source-groups { display: grid; grid-template-columns: repeat(3, 1fr); gap: 17px; }
.source-groups article { padding: 26px; background: #fff; border: 1px solid var(--line); border-radius: 17px; }
.source-groups h3 { font-size: 1.18rem; }
.source-groups a { display: block; margin: 9px 0; color: #087e77; font-size: .83rem; text-decoration-thickness: 1px; text-underline-offset: 3px; }
.scope-box { display: grid; grid-template-columns: repeat(3, 1fr); gap: 16px; margin-top: 17px; }
.scope-box div { padding: 22px; color: #fff; background: var(--navy); border-radius: 14px; }
.scope-box b { color: var(--orange); }
.scope-box p { margin: 7px 0 0; color: rgba(255,255,255,.66); font-size: .8rem; }
.scope-box code { color: var(--teal-bright); background: rgba(255,255,255,.08); }

footer { display: grid; grid-template-columns: auto 1fr auto; gap: 35px; align-items: center; padding: 35px max(24px, calc((100vw - var(--content)) / 2)); color: #fff; background: #04131f; }
footer p { margin: 0; color: rgba(255,255,255,.55); font-size: .76rem; }
footer > a { color: var(--teal-bright); font-size: .8rem; }

@media (max-width: 1100px) {
  .hero-inner { grid-template-columns: 1fr; min-height: auto; }
  .verdict-panel { max-width: 760px; }
  .hero-metrics { grid-template-columns: repeat(3, 1fr); }
  .economics-grid, .science-overview { grid-template-columns: 1fr; }
  .company-grid, .route-grid { grid-template-columns: repeat(2, 1fr); }
  .timeline { grid-template-columns: repeat(3, 1fr); }
  .timeline article:nth-child(3)::after { display: none; }
  .filter-bar { grid-template-columns: repeat(3, 1fr); }
  .search-field { grid-column: span 2; }
  .china-filter-bar { grid-template-columns: repeat(3, 1fr); }
  .china-filter-bar .search-field { grid-column: span 2; }
}

@media (max-width: 800px) {
  body { font-size: 17px; }
  .site-header { min-height: 64px; }
  .nav-toggle { display: block; }
  .site-header nav { position: absolute; inset: 64px 0 auto; display: none; padding: 20px 24px; background: var(--navy); border-top: 1px solid rgba(255,255,255,.12); box-shadow: 0 20px 35px rgba(0,0,0,.2); }
  .site-header nav.open { display: grid; grid-template-columns: repeat(2, 1fr); }
  .hero-inner { padding-top: 65px; }
  .split-heading, .section-heading.inverse, .price-thesis, .calculator-grid, .strategy-grid, .subsection-heading, .payer-grid { grid-template-columns: 1fr; gap: 25px; }
  .market-controls, .market-summary { grid-template-columns: repeat(2, 1fr); }
  .decision-callout, .ninety-days { grid-template-columns: 1fr; gap: 8px; }
  .timeline { grid-template-columns: repeat(2, 1fr); }
  .timeline article:nth-child(3)::after { display: block; }
  .timeline article:nth-child(even)::after { display: none; }
  .schedule-note-grid, .source-groups, .scope-box { grid-template-columns: 1fr; }
  .metadata-coverage, .china-stats, .profile-grid { grid-template-columns: repeat(2, 1fr); }
  .evidence-stats { grid-template-columns: repeat(3, 1fr); }
  .trial-meta-strip { grid-template-columns: repeat(2, 1fr); }
  .china-filter-bar { grid-template-columns: repeat(2, 1fr); }
  footer { grid-template-columns: 1fr; gap: 18px; }
}

@media (max-width: 560px) {
  body { font-size: 16px; line-height: 1.66; }
  .brand > span:last-child { display: none; }
  .site-header nav.open { grid-template-columns: 1fr; }
  .hero h1 { font-size: 2.75rem; }
  .hero-inner { padding-inline: 20px; }
  .verdict-panel { padding: 25px; }
  .verdict-row { grid-template-columns: 1fr; gap: 4px; }
  .hero-metrics { grid-template-columns: repeat(2, 1fr); padding-inline: 11px; }
  .hero-metrics article { padding: 14px 12px; }
  .section { padding: 78px 18px; }
  .thesis-head { align-items: flex-start; }
  .probability-list { padding-inline: 20px; }
  .economics-panel { padding: 23px 18px; }
  .ladder-row { grid-template-columns: 1fr 78px; }
  .ladder-row i { grid-column: 1 / -1; grid-row: 2; }
  .margin-cases div { grid-template-columns: 1fr 75px; }
  .margin-cases em { grid-column: 1 / -1; text-align: left; }
  .output-panel, .market-controls, .market-summary, .company-grid, .route-grid, .timeline, .evidence-stats { grid-template-columns: 1fr; }
  .split-payment { grid-template-columns: 1fr; }
  .timeline article { min-height: auto; }
  .timeline article::after { display: none !important; }
  .pyramid-level.top { width: 76%; }
  .pyramid-level.middle { width: 89%; }
  .filter-bar { grid-template-columns: 1fr; }
  .search-field { grid-column: auto; }
  .china-filter-bar { grid-template-columns: 1fr; }
  .china-filter-bar .search-field { grid-column: auto; }
  .evidence-warning { display: block; }
  .evidence-warning b { display: block; margin-bottom: 5px; }
  .trial-data-grid { grid-template-columns: 1fr; }
  .metadata-coverage, .profile-grid, .trial-meta-strip { grid-template-columns: 1fr; }
  .trial-card-head, .trial-card-actions, .trial-quick summary { padding-inline: 17px; }
  .trial-card-actions { align-items: flex-start; flex-direction: column; }
  .trial-card-actions > span { text-align: left; }
  .trial-body { padding-inline: 17px; }
  #trial-dialog-content, #china-dialog-content { padding: 23px 17px; }
  .dialog-heading { grid-template-columns: 1fr; }
  .evidence-dialog { width: calc(100% - 18px); max-height: 94vh; border-radius: 15px; }
}

@media (prefers-reduced-motion: no-preference) {
  .button, .company-card { transition: transform .2s ease, box-shadow .2s ease; }
}